Our hearts pump some 50 million gallons of blood in our lifetime, and our arteries take a beating because of it. Arteries have the critical task of withstanding the high blood pressure that comes with each heart stroke. To do this, arteries are lined with thick vascular smooth muscle cells (VSMCs) that contract and relax to control blood pressure and secrete proteins to cushion against each and every heartbeat. In this image, human embryonic stem cells have been transformed into VSMCs as shown by smooth muscle-specific markers in red and green. Creating VSMCs will be useful to study vascular abnormalities found in several diseases, including muscular dystrophy.